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Nearly three years after the looks of SARS-CoV-2, it’s clear that vaccines haven’t eradicated the pandemic. On the eve of a brand new vaccination marketing campaign, let’s take inventory with Jean-Marc Sabatier*.
Vaccines towards Covid-19 have deleterious results that generally trigger vascular accidents, thrombosis and different blood anomalies. How do you clarify this?
SARS-CoV-2 an infection results in blood clotting abnormalities in about 15% of contaminated individuals. The identical phenomenon is noticed in vaccinated individuals. About 70-80% of individuals with extreme types of Covid-19 have coagulation problems. These abnormalities are because of dysfunction of the host renin-angiotensin system (RAS) induced by the viral Spike protein, and overactivation of its “deleterious” human AT1R receptor. The RAS is a serious hormonal and physiological system in our physique that controls renal, pulmonary, cardiovascular autonomic features, in addition to innate immunity, and numerous microbiota (together with the intestine microbiota). The RAS is ubiquitous and is discovered within the numerous organs and tissues of our physique.
In brief, Covid-19-associated blood clotting abnormalities (ensuing from SARS-CoV-2 an infection or anti-Covid-19 vaccine injections) are – besides in particular circumstances – associated to RAS dysfunction (through overactivation of its AT1R receptor induced by the binding of the viral or vaccine Spike protein to the mobile goal receptor ECA2).
What position can the SARS-CoV-2 Spike protein play in purple blood cells?
Purple blood cells (produced within the bone marrow by hematopoietic stem cells) are anucleate cells (in mammals) which can be accountable, amongst different issues, for transporting oxygen (oxygen or O2) from the lungs to different tissues and cells within the physique. For this very important perform, these blood cells include hemoglobin able to binding oxygen. It’s notable that the position of purple blood cells just isn’t restricted to oxygen transport: they regulate blood pH, transport immune complexes (because of a floor molecule referred to as CD20) and CO2 produced by the cells.
-Aren’t purple blood cells the little troopers accountable for defending us towards viruses, micro organism and different pathogenic germs?
Purple blood cells are immediately concerned in our physique’s response towards microbes. They’ve a considerable amount of A-glycophorins on their floor (a million receptors per purple blood cell), which function a “decoy” for viral proteins (such because the SARS-CoV-2 or vaccine protein Spike). Thus, these blood cells act as “traps” to neutralize circulating pathogens (or to lower their circulating load), through a direct interplay with their floor proteins. It seems then potential that the Spike protein produced or contained within the anti-Covid-19 vaccines interacts with the purple blood cells modifying their properties and habits.
By what course of?
SARS-CoV-2 -via the Spike protein- induces RAS dysfunction through an overactivation of its “deleterious” receptor AT1R. The overactivated AT1R receptor (by the viral or vaccine Spike protein) is pro-hypertensive, pro-inflammatory, pro-oxidant, pro-angiogenic, pro-thrombotic, pro-fibrosing, pro-hypertrophying and causes nitric oxide (NO) to fall. Overactivated AT1R causes hypoxemia (low oxygen ranges within the blood) and hypoxia (a state of diminished oxygen availability within the tissues). Recall that overactivation of AT1R (of the RAS) is chargeable for macrophage activation syndrome (MAS) and related hemophagocytosis, which destroys purple blood cells and their precursors within the bone marrow. All these knowledge counsel a potential harm to the integrity of purple blood cells.
Let’s speak about vaccines. It has been mentioned that they might include graphene. Your opinion?
Graphene and its derivatives, together with graphene oxide, are usually not described (by producers and WHO) as constituents of vaccines at present used towards SARS-CoV-2 and Covid-19. The presence of such nanomaterials is nonetheless talked about by many authors and experimenters. It will be very severe if the presence of such compounds have been actual for causes of well being transparency and vaccine security (though it’s not acceptable to speak about vaccine security within the context of anti-Covid-19 pseudo-vaccines).
Graphene is fabricated from carbon (it’s a single layer of carbon atoms organized in honeycombs). With its derivatives, graphene presents distinctive potentialities and physico-chemical properties when it comes to lightness, transparency, flexibility, resistance (resistance to breakage 100 occasions increased than that of metal), stability, electrical conduction, magnetism (solely in non-natural circumstances), potential supply of vitality (because of vibratory actions), and clear vitality storage (graphene battery). The fields of utility of those supplies are at present increasing as ultra-sensitive sensors/biosensors, biocatalysts, microchips and others, in addition to in nanomedicine (primarily as a vector for gene remedy and vaccine platform).
Are these nanoparticles current in vaccines in your opinion?
The key issues posed by the presence of carbonaceous nanomaterials of the graphene or by-product kind would doubtlessly be a “deleterious” inflammatory response with oxidative stress, cell demise (by apoptosis, necrosis and/or autophagic dysfunction) a direct toxicity on organs (particularly the lungs and the mind), a genotoxicity (alteration of the DNA which is a supply of cancers and/or deficiencies transmissible to the next generations), in addition to the biodegradability (catabolism) and its penalties on the organism. It’s noteworthy that thus far, undesirable results of those nanomaterials (e.g. graphene oxide) have already been reported on sure cell sorts (together with nerve and lung epithelial cells), and on dwelling organisms together with vegetation (through carbon nanotube-enriched soil). It seems that the human enzyme myeloperoxidase (MPO) produced by white blood cells (neutrophilic granulocytes belonging to innate immunity) would be capable of degrade graphene oxide; these immune cells -in cost of eliminating microbes and international our bodies within the organism- are strongly represented within the lungs. Lastly, graphene nanoparticles (and its derivatives) seem all of the extra poisonous as their dimension is vital. Within the case of an efficient presence of graphene oxide, or different associated compound in mRNA vaccines (which stays to be formally demonstrated to my information), a speedy elimination by a mechanism of phagocytosis of specialised immune cells is possible.
What are the implications of a number of vaccinations?
The results of vaccine injections must be kind of “seen” and long-lasting relying on the person (age, gender, well being standing, genetic make-up, and many others.) and the variety of injections acquired. For my part, the actual drawback linked to the a number of injections of those pseudo-vaccines would be the altered purposeful potential of the host’s blood. Certainly, these repeated vaccine injections will inevitably result in a deficiency of the innate immune system (instant non-specific immunity) and, consequently, to a deficiency of the adaptive/acquired immune system (later immunity of about 4 days and particular to the infectious agent, or different), i.e. to a generalized deficiency of the immune system. Thus, it appears to me pressing and very important to cease these ineffective and deleterious injections, as a result of they may inexorably result in a serious disruption of the immune system within the “vaccinated” individuals. The acquired immunodeficiency syndrome (AIDS) could possibly be an enduring modification of immunity within the “vaccinated” host, which may result in the onset and/or improvement of varied pathologies (cancers, autoimmune ailments, neurodegenerative ailments, and many others.).
Do the brand new bivalent vaccines current the identical dangers?
The well being authorities (European Medicines Company, and Haute Autorité de Santé) have simply accredited injections with the brand new “bivalent” vaccines towards Covid-19, in addition to their coupling with the flu vaccine. It’s noteworthy that these approvals by the authorities are usually not primarily based -to date- on any scientific trial.
An actual vaccine should meet two standards: efficacy and security. So far as efficacy is anxious, these new pseudo-vaccines is not going to be far more efficient than their predecessors, even with the addition of 1 or two messenger RNAs coding for the modified Spike proteins of the Omicron variant (BA.1) and its sublineages BA.4, BA.5. It’s clear that the brand new mRNA vaccines is not going to stop both an infection or transmission of SARS-CoV-2. These vaccines is not going to be with out unwanted side effects as a result of the 2 or three messenger RNAs, injected concurrently, are anticipated to provide Spike proteins which can be nonetheless doubtlessly able to binding to the ACE2 receptor of goal cells, resulting in RAS dysfunction and the potential triggering of Covid-19 ailments. The hazards related to lipid nanoparticles are nonetheless current in these new vaccines. In brief, these will present nothing when it comes to safety. These extra vaccine injections will solely enhance the danger of creating extra extreme types of the illness through the ADE and ERD an infection facilitation phenomena (along with the potential toxicity of lipid nanoparticles current within the vaccines). The benefit-risk stability stays clearly unfavorable with the brand new vaccines nonetheless primarily based on the viral Spike protein. Ideally, from a well being perspective, these pseudo-vaccine boosters must be stopped.
*Jean-Marc Sabatier is Director of Analysis on the CNRS and holds a doctorate in Cell Biology and Microbiology. Editor-in-Chief of the worldwide scientific journals: “Coronaviruses” and “Infectious Problems – Drug Targets”. He speaks right here in his personal title.
Vaccines : the brand new bivalent Moderna nonetheless not advisable
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