These two illnesses are complicated due to their non-specific signs. The trigger is the RAS, the hormonal/physiological system discovered all through the human physique.

Lyme illness is a zoonosis, an infectious illness transmissible from animals to people, which may happen following a tick chunk contaminated with the bacterium Borrelia burgdorferi sensu lato. This bacterium causes the illness recognized in the US, in Lyme, Connecticut, within the early Nineteen Seventies. In 2019, the Sentinel community listed 50,133 circumstances in metropolitan France, primarily within the Grand Est, Bourgogne-Franche-Comté, Auvergne, Rhône-Alpes and Nouvelle Aquitaine.

A number of signs

Lyme illness is commonly tough to diagnose as a result of it could possibly have an effect on totally different organs and trigger joint and muscle ache, neurological issues, visible and sleep issues, pores and skin issues, listening to issues, cardiovascular issues, persistent fatigue, fever, coughing, inflammatory illnesses (resembling myocarditis, pericarditis, uveitis, conjunctivitis), digestive issues, and so forth. In complete, greater than 70 signs are related to Lyme illness.
The scientific image is just like that of Covid-19: fever, cough, fatigue, lack of scent or style, muscle and joint ache, problem respiration, cardiovascular issues, chest ache, pores and skin issues, immune deficiency, photophobia, and so forth.

In all places within the human physique

For Jean-Marc Sabatier*, each illnesses, Lyme and Covid-19, have an effect on the functioning of the renin-angiotensin system (RAS). The renin-angiotensin system is a ‘key’ hormonal/physiological system,” he explains, “which is discovered all through the human physique, together with the lungs, kidneys, intestines, coronary heart, mind, spleen, pancreas, adrenal glands, pores and skin, reproductive organs, blood vessels, in addition to cells of the “innate” immune system (circulating monocytes, macrophages, dendritic cells, granulocytes, mast cells, pure killer cells). The RAS controls renal, pulmonary and cardiovascular capabilities, in addition to “innate” immunity (instant “non-specific” response to pathogens) and varied microbiota, together with the intestinal microbiota.

What does this inform us?

Lyme illness is related to RAS dysfunction induced by Borrelia micro organism. And will probably be handled, in parallel to antibiotics, by RAS inhibitors (ACE receptor inhibitors, AT1R receptor antagonists (sartans), dexamethasone, thymoquinone, vitamin D and angiotensin metabolites concerned in RAS down-regulation, and so forth).
SARS-CoV-2, Borrelia micro organism in addition to the coronavirus of FIP in cats have in widespread the dysfunction of this ubiquitous system, current within the varied organs and tissues of the mammalian organism.

*Jean-Marc Sabatier is Director of Analysis on the CNRS and holds a PhD in Cell Biology and Microbiology and an HDR in Biochemistry. Editor-in-Chief of the worldwide scientific journals: “Coronaviruses” and “Infectious Problems – Drug Targets”. He’s talking in his personal identify.

What the cat tells us about Covid-19